Characteristics of Children with OCD and Tic Disorders: A Systematic Clinical Evaluation

Characteristics of Children with OCD and Tic Disorders: A Systematic Clinical Evaluation
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This study explores the clinical features that define a homogeneous subgroup of children with OCD and tic disorders including Tourettes disorder. The presence of tics or OCD disorder, pediatric onset, episodic symptom course, association with GAHS infection, and neurological abnormalities were analyzed.

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1. PANDAS Sven Wiklund Barnneurolog Barnkliniken KRYH

4. Systematic clinical evaluation of children with Sydenhams chorea suggested that specific clinical characteristics might define a homogeneous subgroup of patients with OCD and tic disorders, including Tourettes disorder. 1. Presence of a tic and/or OCD disorder. 2. Pediatric onset. 3. Episodic course of symptom severity. 4. Association with GAHS infection. 5. Association with neurological abnormalities.

5. 184 trffar i PubMed

7. Fem kriterier, enligt Archelos och Hartung, fr att fastlla ett samband mellan antikroppar och neurologisk sjukdom 1. Identifierade antikroppar 11 studier talar fr en koppling och 10 studier emot. 2. Autoantikroppar identifierade i CNS hos mnniska. 0 studier. 3. Autoantigen inducerar symtom hos frsksdjur. 1 studie, som talar fr. 4. Autoantkroppar inducerar symtom hos frsksdjur 2 studier talar fr och 1 emot. 5. Postitivt svar p immunmodulerande behandling 1 RCT 3 case studies med sammanlagt 6 patienter

8. What is the mechanism behind this phenomenon? At present, it is unknown

9. The children usually have dramatic, "overnight" onset of symptoms, including motor or vocal tics, obsessions, and/or compulsions .

10. Is there a test for PANDAS? No. The diagnosis of PANDAS is a clinical diagnosis, which means that there are no lab tests that can diagnose PANDAS

11. The treatments for children with PANDAS are the same as if they had other types of OCD or tic disorders. Children with OCD, regardless of whether or not their illness is strep triggered, benefit from cognitive behavioral therapy and/or anti-obsessional medications. At this time, however, there isn't enough evidence to recommend the long-term use of antibiotics.

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