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Clinical Guidelines. Veli Bi ç er. Outl ine. Evidence-Based Medicine Clinical Guidelines Developing Guidelines Computerized Clinical Guidelines Arden Syntax GEM PRO forma & Arezzo. Outl ine cont’d. Asbru & DeGel GUIDE & NewGuide MyHeart EON & Athena GLIF Towards Standardization
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Clinical Guidelines Veli Bi ç er

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Outl ine Evidence-Based Medicine Clinical Guidelines Developing Guidelines Computerized Clinical Guidelines Arden Syntax GEM PRO forma & Arezzo

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Outl ine cont'd Asbru & DeGel GUIDE & NewGuide MyHeart EON & Athena GLIF Towards Standardization What is next? References

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Evidence-Based Medicine Advocates the utilization of progressive "best" investigative proof from human services research as the premise of deciding. It offers: Objective approach to decide high caliber and wellbeing measures The procedure of transfering clinical discoveries into practice Potential to diminish human services costs.

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Clinical Guidelines "deliberately created articulations to help professionals and patients on choices about fitting social insurance for particular circumstances" [Field and Lohr [1990] ]

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Developing Guidelines Prioritizing Guideline Topic: Major reasons for mortality for a populace Uncertainty about the fittingness of medicinal services Need to moderate assets in giving consideration Cardiovascular Diseases is a noteworthy class.

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Developing Guidelines The subject is generally refined subsequent to the assignment of building up a rule for Cardiovascular maladies is extensive Care Elements: Primary (The underlying and nonspecialized medicinal services) Secondary (Specialist care in a healing facility setting ) Tertiary (Services gave by profoundly specific suppliers and tech.) Aspects of Management: Screening Diagnosis Drug Therapy Risk Factor Management

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Developing Guidelines Setting Inpatient Outpatient Time Frame Emergency Acute Chronic

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Developing Guidelines Identifying and Assessing the confirmation Best done by deliberate survey. The Cochrane Library contains references to more than 218000 clinical trials http://www.cochrane.org/Once accumulated, the proof is deciphered and interpreted into CPG.

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Computerized Clinical Guidelines Most clinical rules are content based All of them is not open online Physicians experience issues in choosing which of numerous rules best relates to their patient An unmistakable requirement for viable rule bolster devices at the purpose of consideration To be successful, these apparatuses: should be grounded in the patient's record must utilize standard therapeutic vocabularies ought to have clear semantics must encourage learning sharing

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Computerized Clinical Guidelines Approaches to Electronic Guideline Representation Formal Representation Specification Encoding rationale into application-particular configuration Guideline Modeling Methodologies: Rule-based: Arden Syntax Logic-based : PRO forma Workflow: GUIDE, GLIF

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Arden Syntax HL7/ANSI standard Current endorsed rendition is 2.1 Standard, formal procedural dialect that speaks to restorative calculations in clinical data frameworks as Medical Logic Modules (MLMs). MLM: an autonomous unit in a wellbeing information base. It contains: Maintenance Information Links to different sources Logic to settle on a solitary choice

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Arden Syntax upkeep: title: Hepatitis B Surface Antigen in Women;; mlmname: hepatitis_B_mlm;; arden: form 2.1;; ... library: catchphrases: hepatitis B; references: 1. Goldman L, Cook EF, et al. A PC convention to anticipate myocardial localized necrosis. N Engl J Med 1988;318(13);; ... learning: information: penicillin_storage := occasion {store penicillin order} ;; bring out: penicillin_storage;; summon: 3 days after time of creatinine_storage;… ;; var1 := call my_interface_function with param1, param2; rationale: if last_creat is not present then alert_text := "No late creatinine accessible. Consider ordering creatinine before giving IV contrast."; conclude genuine; end if;; end:

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Arden Syntax Advantages: Not a full-highlight programming dialect; Suitable for Clinicians. Gives express connections to information, trigger occasions. Characterizes how a MLM can be called (evoked) from a trigger occasion. Brings specific backing for time capacities. HL7/ANSI standard Used by Commercial DSSs.

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Arden Syntax The fundamental arrangement is not fitting for creating complete electronic rule applications Not as decisive as GLIF if there should be an occurrence of a connection with a clinical database to give cautions and updates, the encoding of clinical learning (MLM) may differ because of database mapping, clinical vocabulary.

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GEM Guideline Elements Model XML-based rule markup model International ASTM (American Society for Testing and Materials) standard. The free-content is markup in XML.

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PRO forma A formal information representation dialect EU fourth Framework Health Telematics PROMPT undertaking Guideline is displayed as an arrangement of: Tasks Data Items Tasks are isolated into: Actions Enquiries Decisions Plans PRO forma programming comprises of a graphical manager to bolster the creating procedure, and a motor to execute the rule detail. Two noteworthy instruments: AREZZO, TALLIS

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PRO forma

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AREZZO Software to make and run clinical rules taking into account PRO forma Commercial Two fundamental parts: Composer, Performer PRO forma gives a few tenets bolstered by AREZZO Performer has Microsoft COM Interface

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Asbru The Asgaard venture drove by the Vienna University of Technology and Stanford Medical Informatics, 1998 An undertaking particular and expectation based arrangement representation dialect Embody clinical rules and conventions as time-situated skeletal arrangements Regarding the planning, the arrangements can be Sequential, Parallel, Any-request, Unordered.

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Asbru <plan-library> <library-data title="Skeleton of a Plan Library"/> <library-defs> <domain-defs>… </area defs> <variable-def name="List-1" scalar-or-not="list" type="string"> <comment text="List-1 is a rundown of strings"/> </variable-def> <constant-def name="PI"> <numerical-steady unit="amount" value="3.1415"/> </consistent def> <function-def class-name="asgaard.checkit" technique name="add_em_up" name="add" return-type="length"/> </library-defs> <plans> <plan-group> <plan name="Plan-A">… </plan><plan name="Plan-B">… </plan> </plan-group> </plans> </plan-library>

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Asbru Records can likewise be characterized in space definitions and utilized as an interface to plans

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DeGel Digital Electronic Guideline Library Developed instruments to bolster the improvement and execution of rule applications. "Master doctors can't program in rule particular dialect, while engineers don't comprehend the clinical semantics" Problem: "In what manner will the huge mass of free content rules be changed over to a formal machine-intelligible dialect?"

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DeGel Based on a half and half (different configuration) electronic representation of rules A rule is initially changed over from free content into semantically semi-organized content Then from semi-formal dialect by a restorative master utilizing a markup editorial manager, to a completely formal representation by a learning specialist The momentum default target dialect is Asbru

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DeGel

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DeGel The system gives the accompanying instruments: Uruz - Gradual transformation of free-content clinical rules into a machine-understandable representation in a given target rule philosophy IndexiGuide - Manual or mechanized grouping of clinical rules along various semantic tomahawks Vaidurya - Search and recovery of clinical rules spoke to in free content, or in a semi-organized arrangement that uses the names of a given target cosmology VisiGuide - Visualization and perusing of an arrangement of rules in an objective metaphysics

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Uruz Guideline markup device Similar to GEM Cutter Editor Source rule (free-content) is stacked and set apart up with semantic names of the objective cosmology. The objective cosmology must be Asbru or GEM The outcome is a XML record

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DeGel URUZ

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Uruz Plan Body Builder: Specific to Asbru Used for characterizing rules control structure Decompose activities into nuclear activities and other sub-rules

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IndexiGuide Allows restorative specialists to file the rules with semantic tomahawks Semantic tomahawks can be signs, manifestations, indicative discoveries, issue, medications et cetera. Semantic tomahawks are headers of institutionalized vocabularies, for example, MeSH, ICD-9, CPT

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Vaidurya Guideline inquiry and recovery device The client can seek in light of semantic tomahawks The set apart up rules can likewise be questioned for the presence of the terms inside interior connection

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Visiguide Visualization of different and single rules Free content, semi-organized content and formal dialect (Asbru). Composes the rules along semantic tomahawks

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GUIDE-NewGuide GUIDE 1998 Reengineered to NewGuide in 2002 Laboratory for Medical Informatics, Department of Computer and System Science, University of Pavia, Italy The Guide environment incorporates three principle autonomous modules: Guideline Management System (GlMS) (giving clinical choice backing) Electronic Patient Record (EPR) Workflow Management System (WfMS or CfMS) (giving hierarchical backing)

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GUIDE-NewGuide

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GUIDE-NewGuide "Distinctive perspectives of the formalized learning to permit diverse individuals with various parts (e.g. clinicians, patients, administrators...) to have their own particular connection particular cooperations with the framework" www.openclinical.org For instance, if a rule recommends taking a bl