Colorectal Tumor (CRC).


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second most normal reason for tumor demise (after lung growth) 2001: 130,000 new instances of CRC ... COX-2 not perceptible in ordinary colon but rather in 90% of. CRCs and 40% of ...
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Colorectal Cancer (CRC) Epidemiology, Risk Factors Symptoms, Stages, Therapy 3) Molecular Biology & Pathology Screening

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EPIDEMIOLOGY a standout amongst the most well-known malignancies on the planet US: 4 th most normal growth (after lung, prostate, and bosom diseases) 2 nd most basic reason for malignancy death (after lung disease) 2001: 130,000 new instances of CRC 56,500 deaths brought about by CRC

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Typical locales of rate and sympoms of colon malignancy

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Risk elements for CRC Age Adenomas, Polyps Sedentary way of life, Diet, Obesity Family History of CRC Inflammatory Bowel Disease (IBD) Hereditary Syndromes (familial adenomatous polyposis (FAP))

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Development of CRC aftereffect of transaction amongst natural and hereditary variables Central ecological elements: eating regimen and way of life 35% of all diseases are owing to eat less carbs half 75% of CRC in the US might be preventable through dietary alterations

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Dietary components involved in colorectal carcinogenesis utilization of red meat creature and soaked fat refined starches liquor expanded danger

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Dietary elements embroiled in colorectal carcinogenesis dietary fiber vegetables organic products cell reinforcement vitamins calcium folate (B Vitamin) diminished danger

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Symptoms connected with CRC rectal draining change in inside propensities hindrance stomach torment & mass iron-inadequacy frailty weight reduction loss of hunger night sweats fever

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Staging of CRC TNM framework Primary tumor (T) Regional lymph hubs (N) Distant metastasis (M)

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Staging of CRC Dukes arranging framework A Mucosa 80% B Into or through M. propria 50% C1 Into M. propria, + LN ! 40% C2 Through M. propria, + LN! 12% D distant metastatic spread <5%

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Sites of metastasis Via blood Via lymphatics Per continuitatem Liver Lung Brain Bones Lymph hubs Abdominal divider Nerves Vessels

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Therapy Surgical resection the main healing treatment Likelihood of cure is more noteworthy when malady is identified at early stage Early identification and screening is of urgent significance

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Screening What is screening? a general wellbeing administration in which individuals from a characterized populace are inspected to recognize those people who might profit by treatment to profit: to diminish the danger of an infection or its complexities

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Types of Screening fecal mysterious blood test (FOBT) synthetic test for blood in a feces test. yearly screening by FOBT lessens colorectal disease passings by 33% Flexible sigmoidoscopy can identify around 65%–75% of polyps and 40%–65% of colorectal growths. rectum and sigmoid colon are outwardly reviewed

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Current Screening Guidelines customary screening for all grown-ups matured 50 years or more seasoned is suggested FOBT consistently flexible sigmoidoscopy like clockwork total colon examination by colonoscopy every 10 years or by barium purification each 5–10 years

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Changes bringing about colon disease

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Molecular Biology & Pathology CRCs emerge from a progression of histopathological and atomic changes that change ordinary epithelial cells Intermediate stride is the adenomatous polyp Adenoma-Carcinoma-Sequence (Vogelstein & Kinzler) Polyps happen all around in FAP, yet FAP represents just 1% of CRCs Adenomatous Polyps as a rule populace: 33% at age 50 70% at age 70

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Mutations in the APC pathway cause expanded multiplication

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MMR surrenders offer ascent to TGF-beta RII transformations, which avoid cell cycle inhibitor (p15) and protease inhibitor (PAI-1) expression

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- 1 COX - 2 Cyclooxygenase (COX) cell film lipids Phospholipase A 2 arachidonic corrosive (aa) headache medicine ibuprofen indomethacin prostaglandins

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COX and CRC COX-2 not recognizable in typical colon but rather in 90% of CRCs and 40% of adenomas Animal models: COX-restraint results in half lessening of carcinomas and >90% decrease of adenomas Epidemiological studies: patients frequently taking headache medicine demonstrated 40-half diminished danger of CRC But: insignificant viable measurements and length of treatment have not yet been resolved

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Microenvironment Control components of mitosis & apotosis lost High metabolic rates, glycolysis (Warburg), high lactic corrosive yield Result: antagonistic microenvironmental conditions (Hypoxia, low pH, low glucose, free oxygen radicals)

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Hypoxia Central element for tumor development and spread Correlated to tumor hypoxia: Therapy result & probablility of metastasis Hypoxia applies particular weight hereditary shakiness results in survival of cells better adjusted to absence of oxygen Evolution of profoundly forceful tumor cells

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CRC and the Internet "Join to get an email message reminding you to have your colon screened at www.wewantthebestforyou.com "

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Summary CRC is a main source of death Early stages are distinguishable Screening can anticipate CRC Katie Couric: http://www.nccra.com/about/videos.htm

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