Colorectal Tumor (CRC).

Uploaded on:
second most normal reason for tumor demise (after lung growth) 2001: 130,000 new instances of CRC ... COX-2 not perceptible in ordinary colon but rather in 90% of. CRCs and 40% of ...
Slide 1

Colorectal Cancer (CRC) Epidemiology, Risk Factors Symptoms, Stages, Therapy 3) Molecular Biology & Pathology Screening

Slide 2

EPIDEMIOLOGY a standout amongst the most well-known malignancies on the planet US: 4 th most normal growth (after lung, prostate, and bosom diseases) 2 nd most basic reason for malignancy death (after lung disease) 2001: 130,000 new instances of CRC 56,500 deaths brought about by CRC

Slide 3

Typical locales of rate and sympoms of colon malignancy

Slide 6

Risk elements for CRC Age Adenomas, Polyps Sedentary way of life, Diet, Obesity Family History of CRC Inflammatory Bowel Disease (IBD) Hereditary Syndromes (familial adenomatous polyposis (FAP))

Slide 7

Development of CRC aftereffect of transaction amongst natural and hereditary variables Central ecological elements: eating regimen and way of life 35% of all diseases are owing to eat less carbs half 75% of CRC in the US might be preventable through dietary alterations

Slide 8

Dietary components involved in colorectal carcinogenesis utilization of red meat creature and soaked fat refined starches liquor expanded danger

Slide 9

Dietary elements embroiled in colorectal carcinogenesis dietary fiber vegetables organic products cell reinforcement vitamins calcium folate (B Vitamin) diminished danger

Slide 22

Symptoms connected with CRC rectal draining change in inside propensities hindrance stomach torment & mass iron-inadequacy frailty weight reduction loss of hunger night sweats fever

Slide 23

Staging of CRC TNM framework Primary tumor (T) Regional lymph hubs (N) Distant metastasis (M)

Slide 24

Staging of CRC Dukes arranging framework A Mucosa 80% B Into or through M. propria 50% C1 Into M. propria, + LN ! 40% C2 Through M. propria, + LN! 12% D distant metastatic spread <5%

Slide 25

Sites of metastasis Via blood Via lymphatics Per continuitatem Liver Lung Brain Bones Lymph hubs Abdominal divider Nerves Vessels

Slide 29

Therapy Surgical resection the main healing treatment Likelihood of cure is more noteworthy when malady is identified at early stage Early identification and screening is of urgent significance

Slide 30

Screening What is screening? a general wellbeing administration in which individuals from a characterized populace are inspected to recognize those people who might profit by treatment to profit: to diminish the danger of an infection or its complexities

Slide 31

Types of Screening fecal mysterious blood test (FOBT) synthetic test for blood in a feces test. yearly screening by FOBT lessens colorectal disease passings by 33% Flexible sigmoidoscopy can identify around 65%–75% of polyps and 40%–65% of colorectal growths. rectum and sigmoid colon are outwardly reviewed

Slide 32

Current Screening Guidelines customary screening for all grown-ups matured 50 years or more seasoned is suggested FOBT consistently flexible sigmoidoscopy like clockwork total colon examination by colonoscopy every 10 years or by barium purification each 5–10 years

Slide 41

Changes bringing about colon disease

Slide 42

Molecular Biology & Pathology CRCs emerge from a progression of histopathological and atomic changes that change ordinary epithelial cells Intermediate stride is the adenomatous polyp Adenoma-Carcinoma-Sequence (Vogelstein & Kinzler) Polyps happen all around in FAP, yet FAP represents just 1% of CRCs Adenomatous Polyps as a rule populace: 33% at age 50 70% at age 70

Slide 43

Mutations in the APC pathway cause expanded multiplication

Slide 44

MMR surrenders offer ascent to TGF-beta RII transformations, which avoid cell cycle inhibitor (p15) and protease inhibitor (PAI-1) expression

Slide 45

- 1 COX - 2 Cyclooxygenase (COX) cell film lipids Phospholipase A 2 arachidonic corrosive (aa) headache medicine ibuprofen indomethacin prostaglandins

Slide 46

COX and CRC COX-2 not recognizable in typical colon but rather in 90% of CRCs and 40% of adenomas Animal models: COX-restraint results in half lessening of carcinomas and >90% decrease of adenomas Epidemiological studies: patients frequently taking headache medicine demonstrated 40-half diminished danger of CRC But: insignificant viable measurements and length of treatment have not yet been resolved

Slide 47

Microenvironment Control components of mitosis & apotosis lost High metabolic rates, glycolysis (Warburg), high lactic corrosive yield Result: antagonistic microenvironmental conditions (Hypoxia, low pH, low glucose, free oxygen radicals)

Slide 48

Hypoxia Central element for tumor development and spread Correlated to tumor hypoxia: Therapy result & probablility of metastasis Hypoxia applies particular weight hereditary shakiness results in survival of cells better adjusted to absence of oxygen Evolution of profoundly forceful tumor cells

Slide 50

CRC and the Internet "Join to get an email message reminding you to have your colon screened at "

Slide 51

Summary CRC is a main source of death Early stages are distinguishable Screening can anticipate CRC Katie Couric:

View more...