Genetic Effects of Radiation .


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Single quality mutationChromosome aberrationsRelative versus outright change riskDoubling doseHeritable impacts in humansRisk gauges for hereditable impacts. Hereditary ailments are credited to transformations happening in germ cells and are transmitted to descendants (inherited illnesses).. Unconstrained change rates are expanded by radiation presentation.
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Slide 1

Inherited Effects of Radiation Lecture 27

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Single quality change Chromosome distortions Relative versus total change hazard Doubling dosage Heritable impacts in people Risk gauges for hereditable effects

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Genetic infections are credited to transformations happening in germ cells and are transmitted to descendants (innate illnesses). Unconstrained change rates are expanded by radiation presentation Three main classes of hereditary ailments: Mendelian Chromosomal Multifactorial

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Mendelian Inheritance Mendelian Diseases Autosomal predominant Autosomal passive X-connected

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Chromosomes Homologous Heterologous Homozygous Heterozygous

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Somatic Cells Process of Division Mitosis Germinal Cells Meiosis

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Cell Division and Chromosome Number in Sex Cells

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Spermatogonia Primary spermatocytes Secondary spermatocytes Spermatids Spermatozoa Germ cell generation in the male warm blooded animals Spermatogenesis

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Germ cell creation in the female well evolved creatures Oogenesis Oogonia Primary oocyte Secondary oocyte Ootids Oocyte

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Chromosome Number

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Chromosomal variations Gross anomalies either in structure or number of chromosomes, for example, Robertsonian translocation, monosomy, trisomy and erasure. Multifactorial illnesses Diseases known to have hereditary segment additionally ecological variables: Known to have a hereditary part Transmission design not basic Mendelian Congenital irregularities: congenital fissure with or without congenital fissure; neural tube surrenders Adult onset: diabetes, basic hypertension, coronary illness Interaction with natural components

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Single quality transformation Chromosome deviations Relative versus total change hazard Doubling measurement Heritable impacts in people Risk gauges for hereditable impacts

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Radiation instigated inherited impacts Children of Japanese survivors of nuclear bomb assaults on Hiroshima and Nagasaki. Relative versus coordinate change hazard "If nature can do it, radiation can do it". In an arrangement of qualities: Av of unconstrained change rate Relative transformation hazard = Av of radiation-actuated transformation rate

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Megamouse Project 7 million mice were utilized Five noteworthy conclusions The radiosensitivity of various transformations fluctuates by a huge element of around 35 Dose rate impact was apparent. Constant measurements presentation instigates less transformations Acute dosage introduction prompts more change This is interestingly with Drosophila

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Megamouse Project Five noteworthy conclusions proceeded with The male is more radiosensitive than females. The hereditary impacts of a given radiation measurements can be lessened extraordinarily if a period interim is permitted amongst introduction and origination. The gauge of the multiplying measurements received by BEIR V and UNSCEAR 88 is 1 Gy.

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Single quality transformation Chromosome variations Relative versus outright transformation chance Doubling measurements Heritable impacts in people Risk gauges for hereditable effects

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Doubling Dose The multiplying dosage is the dosage required to twofold the unconstrained change rate. A low multiplying measurements (5-150 R) for transformations was evaluated from organic product fly tests. Innate impacts are total. Overabundance frequency of leukemia was obvious yet considerably bigger number of strong tumors did not show up until numerous years after the fact in Japanese survivors of the A-bomb assault.

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Single quality transformation Chromosome distortions Relative versus total transformation hazard Doubling measurement Heritable impacts in people Risk gauges for hereditable effects

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Radiation and Sex Cells Females Males Resistant Post-oogonial cells Sensitive follicles Permanent sterility 250-600 rad (2.5 to 6 Gy) 20 rad/yr (0.2 Gy/yr) Pronounced hormonal lopsidedness Resistant Post-spermatogonial cells Sensitive Stem cells Temporary sterility 15 rad (0.15 Gy) 40 rad/year (0.4 Gy/yr) Permanent sterility 350-600 rad (3.5 to 6 Gy) 200 rad/yr (2 Gy/yr) No critical hormonal irregularity

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Hereditary impacts of radiation in people

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