Impersonating The unstoppable force of life.


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Emulating The compelling force of nature. Manufactured Physicist Erik Sorensen: Building Mending Atoms. Sorensen Imitates Nature . Manufactured physicist Erik Sorensen makes particles to recuperate ailment . Photograph: Brian Wilson. Nature's chemicals May hurt or mend Are the wellsprings of numerous medications
Transcripts
Slide 1

Impersonating Mother Nature Synthetic Chemist Erik Sorensen: Building Healing Molecules

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Sorensen Emulates Nature Synthetic scientific expert Erik Sorensen makes atoms to mend malady Photo: Brian Wilson Nature’s chemicals May hurt or recuperate Are the wellsprings of numerous pharmaceuticals Can be orchestrated by researchers Question: Can substance weapons be useful?

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Answer: Yes Chemical weapons can be useful Snakes, bugs, and ocean snails use venom to execute prey Hemlock trees secure themselves with toxic substance Bacteria and parasites use poisons to battle adversaries

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Kill prey Protect from predators Reduce rivalry for assets Kill infections, microbes, and growth cells Suppress the invulnerable framework Treat coronary illness and sorrow Nature’s Chemical Weapons Chemicals from plants, creatures, organisms, and microscopic organisms In nature In solution

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From Plant to Medicine In nature, foxglove is harmful. In pharmaceutical, it is utilized to make digoxin, a medication utilized for heart disappointment and unpredictable pulse In nature, opium is a wonderful blossom. In drug, it is utilized to make morphine, an in number painkiller Photo: Wikipedia Commons

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From Mold to Medicine Penicillin is a typical anti-toxin used to cure contaminations The penicillin atom began its life as a mold Credit: Christin L. Case

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How to Make a Molecule Step 1: Know every one of the particles in the objective particle, how they associate with one another, and how they fit together in 3-dimensional space Step 2: Choose a couple beginning materials (iotas) and pour or scoop them one-by-one into a glass flagon Step 3: Design a progression of concoction responses that will persuade the particles to frame the objective particle by connecting at the right places, discharging unneeded parts, or accurately swapping one iota for another

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Adapting to Nature in Short Supply Taxol ® A medication used to treat tumor Originally made from the bark of gathered Pacific yew trees, which are rare Now produced from Plant cells developed in the lab Needles from homestead raised or wild yew trees Credit: National Institutes of Health

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Cyclostreptin: a Self-Made Molecule An atom with potential malignancy slaughtering properties Structure is 6 synthetic rings with a spine of 5-6 carbon molecules The molecule’s name Cyclo: rings are intertwined in an entangled course of action Streptin: substance was disconnected from Streptomyces microorganisms An uncommon, combined particle, in that it can suddenly overlay into its last shape

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Tools and Techniques Chemical responses Bioprospecting Magnetic reverberation imaging and X-beam crystallography What apparatuses inaccessible in nature can scientific experts utilization to assist them with making nature’s atoms? What are a ways\' percentage researchers do this? How do these instruments help engineered scientific experts?

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Research Applications What are a worries\' portion of individuals why should restricted bioprospecting?

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