Instrument of Hormone Action .


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Instrument of Hormone Activity. Instrument of Hormone Activity. Receptor Structure. Component of Hormone Activity. LH. Adenylate Cyclase. R. C. Protein Hormones (cAMP second flag-bearer). G. Plasma Film. Receptor. Protein Kinase A (PKA). S-ER Steroid Blend. Mitochondria. Core.
Transcripts
Slide 1

Component of Hormone Action

Slide 2

Mechanism of Hormone Action

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Receptor Structure

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Mechanism of Hormone Action LH Adenylate Cyclase R C Protein Hormones (cAMP second errand person) G Plasma Membrane Receptor Protein Kinase A (PKA) S-ER Steroid Synthesis Mitochondria Nucleus DNA Protein R-ER Protein Synthesis (Enzymes)

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Mechanism of Hormone Action LH Adenylate Cyclase cAMP ATP R C Protein Hormones (cAMP second envoy) G Plasma Membrane Receptor Protein Kinase A (PKA) S-ER Steroid Synthesis Mitochondria Nucleus DNA Protein R-ER Protein Synthesis (Enzymes)

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Mechanism of Hormone Action LH Adenylate Cyclase cAMP ATP R C (+ PO 4 ) Histones Nucleus DNA mRNA Protein Hormones (cAMP second detachment) G Plasma Membrane Receptor Protein Kinase A (PKA) S-ER Steroid Synthesis Mitochondria Protein R-ER Protein Synthesis (Enzymes)

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Mechanism of Hormone Action LH Adenylate Cyclase cAMP Testosterone ATP R C (+ PO 4 ) Histones Nucleus DNA mRNA Protein Hormones (cAMP second delegate) G Plasma Membrane Receptor Protein Kinase A (PKA) S-ER Steroid Synthesis Mitochondria Cholesterol Pregnenolone Cholesterol Protein R-ER Protein Synthesis (Enzymes)

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Mechanism of Hormone Action LH Adenylate Cyclase cAMP Testosterone ATP R C (+ PO 4 ) Histones Nucleus DNA mRNA Protein Hormones (cAMP second ambassador) G Plasma Membrane Receptor Protein Kinase A (PKA) S-ER Steroid Synthesis Mitochondria Cholesterol Pregnenolone Cholesterol Protein R-ER Protein Synthesis (Enzymes)

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cAMP Second Messenger Hormones Anterior Pituitary Hormones LH, FSH, Prolactin STH, ACTH , TSH Placental Hormones HCG, eCG

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GnRH PIP 2 G-protein PLC Protein Kinase C R Secretory Granules Protein Hormones (Ca 2+ Second Messenger) Plasma Membrane Receptor Ca 2+ Endoplasmic Reticulum Plasma Membrane

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GnRH PIP 2 PIP 2 G-protein PLC Protein Kinase C R Secretory Granules Protein Hormones (Ca 2+ Second Messenger) Plasma Membrane Receptor Ca 2+ Endoplasmic Reticulum Plasma Membrane

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GnRH DAG PIP 2 PIP 2 G-protein PLC Protein Kinase C IP 3 Ca 2+ R Secretory Granules Protein Hormones (Ca 2+ Second Messenger) Plasma Membrane Receptor Ca 2+ Endoplasmic Reticulum Plasma Membrane

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Ca 2+ GnRH DAG PIP 2 PIP 2 G-protein PLC Protein Kinase C IP 3 Ca 2+ R Secretory Granules Protein Hormones (Ca 2+ Second Messenger) Plasma Membrane Receptor Ca 2+ Endoplasmic Reticulum Plasma Membrane

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Ca 2+ GnRH DAG PIP 2 PIP 2 G-protein PLC Protein Kinase C IP 3 Ca 2+ R Secretory Granules Fusion LH Protein Hormones (Ca 2+ Second Messenger) Plasma Membrane Receptor Ca 2+ Endoplasmic Reticulum Plasma Membrane

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Calcium Second Messenger Hormones GnRH triggers arrival of LH in front pituitary Oxytocin triggers compressions of smooth muscle PGF 2  triggers apoptosis of cell restraint of progesterone union

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Steroid (estrogen) Diffusion? Change in Cell Physiology New Protein Receptor R-ER Protein amalgamation mRNA Steroid Hormone Action Cell Membrane Cytoplasm Nucleus DNA

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Steroid Hormone Mechanism Estradiol Testosterone, Dihydrotestosterone Cortisol

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Neuro-secretory Cells Hypothalamus Feedback Loops Releasing Hormones Polypeptides Portal Vein - Anterior Pituitary - Gonadotropins: FSH, LH Proteins Blood Stream Gonads Why just consequences for [ ] Receptor on Cell Surface target organs Cyclic AMP inside cell Testosterone { Steroid Hormone Production Estradiol Progesterone Blood Stream Bound to Protein

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Endocrine Feedback Loops Negative gonadal steriods Testosterone, Progesterone, Estradiol Protein hormones inhibin Positive Gonadal steroids estradiol

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