Lethal New Source Survey.

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Wellbeing danger evaluation includes an extensive investigation of the scattering of ... Rules for Health Risk Assessment. The Office of Environmental Health Hazard ...
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Lethal New Source Review Lance Ericksen Engineering Division Manager MBUAPCD

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What are Toxic Air Contaminants "All substances are toxins; there is none which is not a toxic substance. The right measurements separates a toxic substance from remedy." Theophrastus Bombastus von Hohenheim (Paracelsus, 1493-1541)

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Toxic Identification Process

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What is Toxic New Source Review? By tenet or arrangement most areas survey new wellsprings of dangerous outflows Districts may have distinctive methodologies on: Risk Characterization Cancer and Non-Cancer hazards How populaces are uncovered

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Overview of Health Risk Assessment (HRA) Components of Risk Assessment Guidance Documents for HRA Risk Characterization Cancer and Non-Cancer dangers Exposure Routes Health Effects Databases

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Risk Assessment

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What is Health Risk Assessment? Wellbeing hazard evaluation includes a thorough examination of the scattering of discharged chemicals noticeable all around and the degree of human presentation by means of significant pathways ( introduction appraisal ), the toxicology of those chemicals ( measurements reaction evaluation ), and the estimation of malignancy danger and non-tumor wellbeing effects to the uncovered group ( hazard portrayal )

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Toxic NSR Process Identify Toxic Air Contaminants (TACs) that are radiated Model Emissions from the Source Characterize Risk Cancer and Non-Cancer dangers Compare to Established Standards

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Guidelines for Health Risk Assessment The Office of Environmental Health Hazard Assessment (OEHHA) is required to create rules for directing wellbeing hazard appraisals under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360 (b) (2)). OEHHA was additionally required to build up a stochastic or probabilistic way to deal with presentation evaluation This lead to the advancement of the Air Toxics Hot Spot Program Guidance Manual for Preparation of Health Risk Assessments (OEHHA 2003). Accessible on www.oehha.ca.gov OEHHA created four Technical Support Documents (TSDs) in light of this statutory prerequisite which gave the investigative premise to values utilized as a part of surveying danger from presentation to office discharges.

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Guidelines for Health Risk Assessment (cont\'d) The four TSDs portray intense Reference Exposure Levels (RELs), incessant RELs, malignancy strength variables, and the general introduction evaluation procedure . This Guidance Manual supercedes the danger evaluation strategies exhibited in CAPCOA\'s Risk Assessment Guidelines, 1992,93. The new Guidance Manual overhauls wellbeing impacts values, introduction pathway variates (e.g breathing rates), and exhibits a layered methodology in directing a HRA.

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Risk Characterization Cancer Based on an introduction of breathing the TAC for a long time (wellbeing defensive) Non-Cancer Acute-fleeting abnormal state presentation – by and large one hour might be 4,6, or 7 hours Chronic – long haul low level-annualized found the middle value of over a year

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Measurements for Risk Cancer – growth hazard not surpass of "x" in a million regularly 1 x 10 - 6 , 10x 10 - 6 with TBACT Cancer load not to surpass ordinarily 0.5 Non-disease – Hazard Index (HI) not to surpass typically 1 HI intense = proportion of demonstrated fixation to Acute REL HI endless = proportion of displayed focus to perpetual REL

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Risk Characterization-Cancer hazard Estimate Added lifetime danger of contracting malignancy as a consequence of a given presentation Risk of one in a million(1x10 - 6 ) implies that the individual possibility of contracting tumor has expanded by one chance in a million far beyond foundation and the shot of contracting growth from different elements (e.g. diet, smoking, heredity,etc)

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Risk Characterization-Cancer risk(cont\'d) Carcinogenic inward breath intensity variable (unit hazard component) or oral tumor strength element URF is the assessed likelihood that an individual will contract growth as a consequence of inward breath of a centralization of 1 ug/m3 of the TAC constantly over a time of 70 years and communicated in units of converse fixation as micrograms per cubic meter (ug/m3) - 1 Cancer power element is an upper bound likelihood of creating malignancy accepting persistent lifetime presentation to a substance at a measurement of one milligram for every kilogram of body weight and communicated in units of backwards dosage as an intensity slant, (mg/kg/day) - 1 Breathing rates communicated in units of liters per kilogram of body weight-day (L/kg#BW-day) can be combined with air focuses to gauge measurement in mg/kg-day

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Risk Characterization-Cancer risk(cont\'d Cancer load expanded number of disease cases as an aftereffect of introduction to the TACs Excess disease trouble for a populace unit (city, statistics tract, subarea or framework) is the result of the uncovered populace and the evaluated singular danger from surrounding air.

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Reference Exposure Level (REL) The fixation level at or underneath which no unfavorable wellbeing impacts are expected Based on most touchy, important, antagonistic wellbeing impact reported in the medicinal and toxicological writing. Intended to secure the most delicate people in the populaces by the consideration of edges of wellbeing.

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Risk Characterization for Non-Cancer Risk Hazard Index = Estimate Exposure Level/Reference Exposure Levels A HI of 1 or less demonstrates that no unfriendly wellbeing impact are normal HI > 1 shows that unfavorable effects can be relied upon Simultaneous presentation to two or more TACs at subthreshold levels may bring about a poisonous reaction. For this situation, the Total HI is evaluated for the individual target organs.

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Central or fringe sensory system Cardiovascular or blood framework Immune System Kidney Respiratory framework Reproductive framework Skin Eye Gastrointestinal framework and liver Risk Characterization for Non-Cancer Risk (cont\'d) Total Hazard Index Summation of HI for every objective organ for introduction to a blend of TACs Toxicological Endpoints Considered

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Exposure Routes

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Health Effects Databases ARB (TAC records, the "Hot Spots" emanations stock, ARB\'s encompassing air toxics checking system) U.S. EPA Hazardous Substances Data Bank (HSDB), Integrated Risk Information System (IRIS), Toxic Release Inventory (TRI)], World Health Organization International Agency for Research on Cancer (IARC) Monographs On the Evaluation of Carcinogenic Risks to Humans OEHHA Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65) Others Handbook of Chemistry and Physics and the Merck Index

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District Rules South Coast Rule 212 Bay Area Regulation 2, Rule 5 San Joaquin Valley Integrated Air Toxics Program Monterey Bay Rule 1000

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