Lymphocyte advancement and survival Chapter 7Slide 2
Objectives Describe or build stream outlines demonstrating the phases being developed of B cells and T cells, including: The general attributes (surface markers, and so forth) of lymphocytes at every stage Other sorts of cells or cytokines that are required at every phase What happens to cells which neglect to finish a phase of improvement Predict how particular hereditary imperfections would change lymphocyte improvementSlide 3
Hematopoiesis Lymphopoiesis mostly happens in focal lymphoid tissuesSlide 4
Testing for suitable antigen acknowledgment properties ( resistance to self) Activation by antigen Differentiation Major phases of advancement in lymphocytes Expression of antigen receptorSlide 5
Overview of B cell advancementSlide 6
Overview of T cell improvementSlide 7
B cell advancement Expression of antigen receptor (immunoglobulin)Slide 8
B cell advancement: Expression of Ig Stromal cells in the bone marrow give cytokines and bolster required to early B cell improvement Interleukin-7 (IL-7) Cell grip particles (CAMs)Slide 9
B cell advancement: Expression of IgSlide 10
B cell improvement: Expression of IgSlide 11
B cell improvement: Expression of IgSlide 12
RAG B cell improvement: Expression of IgSlide 13
B cell advancement: Expression of Ig Rescue of B cells with inefficient rearrangmentsSlide 14
Testing for fitting antigen acknowledgment properties ( resilience to self) B cell improvement Expression of antigen receptor Negative determination: choice of cells that don\'t tie to self antigensSlide 15
B cell advancement: Negative choiceSlide 16
B cell advancement: Negative choice Self-responsive B cells may experience encourage light chain revampSlide 17
B cell improvement: Negative choice Some self antigens are just communicated in the fringe High levels of cross-connecting antigen in outskirts can incite B cell anergySlide 18
Testing for proper antigen acknowledgment properties ( resistance to self) Activation by antigen B cell improvement Expression of antigen receptorSlide 19
B cell advancement: initiation by antigenSlide 20
B cell advancement: enactment by antigen Chemokines draw in and hold B cells in the lymph hubs CXCL13Slide 21
B cell advancement: actuation by antigenSlide 22
Testing for fitting antigen acknowledgment properties ( resilience to self) Activation by antigen Differentiation B cell advancement Expression of antigen receptorSlide 23
B cell improvement: separation Activated B cells experience clonal extension Progeny separate into plasma cells or memory B cells Isotype exchanging and physical hypermutation happenSlide 24
B cell malignancies B cell tumors emerge from cells at different phases of advancement Retain qualities of the ordinary B cell equalSlide 25
Overview of T cell improvementSlide 26
Some lymphoid forebears move to the thymusSlide 27
The significance of the thymus for T cell improvementSlide 29
Testing for proper antigen acknowledgment properties ( resistance to self) Activation by antigen Differentiation T cell improvement Expression of antigen receptorSlide 30
T cell advancement Expression of TCRSlide 31
T cell advancement: articulation of TCR Progenitors landing from the bone marrow don\'t express TCR, CD3, CD4, or CD8 Successful reworking of TCR chain brings about articulation of a pre-T-cell receptor, CD3, CD4, and CD8Slide 32
T cell improvement: articulation of TCRSlide 33
T cell advancement: articulation of TCRSlide 34
T cell improvement: articulation of TCRSlide 35
Testing for suitable antigen acknowledgment properties ( resistance to self) T cell advancement Expression of TCRSlide 36
T cell improvement: choice for self-resistance Selection for self-resilience in T cells requires two phases: Positive choice for capacity to tie to MHC : peptide buildings Negative choice disposes of T cells with high-proclivity authoritative to MHC : self peptide edificesSlide 37
T cell improvement: Positive choiceSlide 38
T cell advancement: Positive choiceSlide 39
T cell improvement: Negative choiceSlide 40
The part of thymic cells in positive and negative choiceSlide 41
Mechanisms of positive and negative choice Mechanisms that separate positive and negative choice are not clear Difference in liking? Different signs required?Slide 42
Testing for suitable antigen acknowledgment properties ( resistance to self) Activation by antigen T cell advancement Expression of TCRSlide 43
T cell improvement: actuation by antigenSlide 44
T cell advancement: initiation by antigen As with B cells, self-receptive T cells can likewise be killed in the fringe Activation-prompted cell passing AnergySlide 45
Testing for fitting antigen acknowledgment properties ( resilience to self) Activation by antigen Differentiation T cell improvement Expression of TCRSlide 46
T cell improvement: separation Activated T cells experience clonal extension Differentiation of descendants into effector or memory cells Cytotoxic T lymphocytes Helper T cells (Th1, Th2) Memory T cellsSlide 47
T cell tumors
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