Nourishment Counseling Advisory group Meeting February 24-25, 2003 Report of the Contaminants and Common Toxicants Subco.


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Nourishment Counseling Board Meeting February 24-25, 2003 Report of the Contaminants and Regular Toxicants Subcommittee (CNTS) Discoveries Henry Kim, Ph.D. Official Secretary, CNTS Bureau of Wellbeing and Human Administrations Presentation Diagram Motivation behind the Subcommittee meeting
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Sustenance Advisory Committee Meeting February 24-25, 2003 Report of the Contaminants and Natural Toxicants Subcommittee (CNTS) Findings Henry Kim, Ph.D. Official Secretary, CNTS Department of Health and Human Services

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Presentation Outline Purpose of the Subcommittee meeting Presentations at the Subcommittee meeting Subcommittee’s discourses and proposals Department of Health and Human Services

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Subcommittee Meeting Purpose Meeting held December 4-5, 2002 Present Components of FDA Draft Action Plan Obtain Subcommittee Recommendations Department of Health and Human Services

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Charge to Subcommittee The Subcommittee was requested that assess whether the exploration steps laid out in FDA’s activity arrangement are logically sufficient to portray and address the general wellbeing criticalness of acrylamide in sustenance Department of Health and Human Services

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Given what we know of acrylamide – toxicology, event, development, introduction, and dangers: Are the examination steps proper to depict and address the general wellbeing noteworthiness of acrylamide in nourishment? Are there holes in the exploration arrangement or ranges where accentuation ought to be expanded? Are there need research needs that ought to be tended to first? Branch of Health and Human Services

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1. Toxicology Dr. Richard Canady, FDA Toxicokinetics Animal cancer-causing agent Human neurotoxicant Reproductive/formative impacts Safety/hazard appraisal Department of Health and Human Services

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2. Event Dr. Steve Musser, FDA Development and execution of a LC/MS/MS technique for the quantitation of acrylamide in a wide mixed bag of nourishments Results of exploratory review information from U.S. sustenances Department of Health and Human Services

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3. Arrangement Dr. Lauren Jackson, FDA Summarized components, forerunners, and variables influencing acrylamide arrangement Identified research needs Discussed FDA’s Draft Action Plan for acrylamide arrangement Understand conditions prompting acrylamide development Develop strategies to forestall or diminish acrylamide development Department of Health and Human Services

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4. Presentation Dr. Michael DiNovi, FDA approach for presentation appraisal Occurrence/Consumption Data Sweden introduction study FAO/WHO introduction study FDA’s starting introduction assessment being directed Department of Health and Human Services

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5. Shopper Risk Dr. David Acheson, FDA Achieving an adjust: The significance of an adjusted eating regimen Risks from introduction to acrylamide in nourishment Potential perils of deficient cooking Department of Health and Human Services

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Other Presentations Opening Remarks - Joseph Levitt, FDA Scientific Overview - Dr. Bernard Schwetz, FDA JIFSAN Workshop - Dr. David Lineback, JIFSAN Public Comments Henry Chin, NFPA Marvin Friedman, SNF Jeff Stier, ACSH Department of Health and Human Services

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Subcommittee Responses to Question 1: Are the examination steps suitable to depict and address open importance of acrylamide in sustenance? YES Supported the general Draft Action Plan Supported the examination steps Department of Health and Human Services

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Subcommittee Responses to Question 2: Are there crevices are in the exploration arrangement or regions where accentuation ought to be expanded? More nitty gritty data on : Risk appraisal Human toxicology and the study of disease transmission contemplates Animal toxicology studies Sampling and investigative variability Food utilization information by different populace bunches Department of Health and Human Services

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Subcommittee Responses to Question 3: Are there need research needs that ought to be tended to first? Ebb and flow methodology is fitting Methodology, event, arrangement, introduction, and afterward chance Explicit proclamation of exploration need Toxicology and danger evaluation studies ought to push ahead rapidly Focus on fast/reasonable test advancement Science-based danger correspondence message Department of Health and Human Services

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Subcommittee Recommendations Toxicology Physiological studies in people retention, digestion system, appropriation, discharge Toxicokinetics investigations of ingested acrylamide in people Animal neurotoxicity and genotoxicity examines Animal bioassay considers for cancer-causing nature Short-term studies Dose-reaction relationship at lower levels - in the middle of NOAEL and tumor delivering measurements Mechanism of activity Biomarker-presentation relationship in smokers Department of Health and Human Services

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Subcommittee Recommendations Epidemiology Highlight a different area on the study of disease transmission in the Draft Action Plan More the study of disease transmission concentrates on in human populaces Identify/study populaces w/higher or lower presentation Confounding variables may constrain legitimacy of study Investigate the study of disease transmission investigations of word related exposures Applicable for nourishment introduction? Branch of Health and Human Services

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Subcommittee Recommendations Exposure Assessment Highlight introduction appraisal component Provide data about databases Improve capacity to visually impaired information – encourage information sharing Statistically focus inspecting adequacy Obtain presentation assessors info on kind of nourishments examined Use sustenance utilization information by different populace bunches Department of Health and Human Services

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Subcommittee Recommendations Risk Assessment Incorporate more data into the Draft Action Plan Importance of danger evaluation Methodology for directing danger appraisal Methods for consolidating creating information Department of Health and Human Services

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Subcommittee Recommendations Risk Communication More accentuation on FDA’s hazard correspondence exercises Provide science-based data for dietary decisions Involve dietetic/sustenance relationship in correspondence endeavors American Dietetic Association American College of Nutrition Disseminate purchaser and cooking messages through augmentation administrations Department of Health and Human Services

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Summary Subcommittee talked emphatically about FDA’s Draft Action Plan Subcommittee by and large concurred with FDA’s approach and arranged examination exercises Subcommittee gave proposals on specific parts of the arrangement Toxicology Epidemiology Exposure evaluation Risk evaluation Risk correspondence Department of Health and Human Services

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