Protein Interactions in and Disease Maricel Kann NIH, Yanay Ofran Columbia, Marco Punta Columbia, and Predrag Radivoja .


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Protein Interactions in (and) Disease Maricel Kann (NIH), Yanay Ofran (Columbia), Marco Punta (Columbia), and Predrag Radivojac (Indiana). Protein Interactions. Protein and diseases. LINKING INTERACTIONS TO DISEASE Analyzing interactions. Protein Interactions. Protein and diseases.
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Protein Interactions in (and) Disease Maricel Kann (NIH), Yanay Ofran (Columbia), Marco Punta (Columbia), and Predrag Radivojac (Indiana)

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Protein Interactions Protein and sicknesses LINKING INTERACTIONS TO DISEASE Analyzing collaborations

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Protein Interactions Protein and illnesses LINKING INTERACTIONS TO DISEASE Analyzing associations

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Protein Interactions Protein and ailments LINKING INTERACTIONS TO DISEASE Analyzing cooperations

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Detecting protein-protein communications High-throughput Two-cross breed systems Fields FEBS (2005) 262 :5391-5399 - Review Mass Spectrometry Mann et al. (2001) Rev Biochem. 70 :437-473 - Review Microarrays ESPEJO et al. (2002) Biochem. J. 367 (697 – 702) Single protein Molecular science

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Expanding protein-protein collaboration DATAbases Sequence likeness Structural closeness De NOVO

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From: A Protein Interaction Map of Drosophila melanogaster Giot, Rothberg et al. Science 302 , 1727-1136 (2003) cooperation outline Expanding protein-protein communication DATAbases Sequence comparability Structural closeness De NOVO Struct2Net: Integrating Structure into Protein-Protein Interaction Prediction Rohit Singh, Jinbo Xu, and Bonnie Berger

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Linking protein-protein associations to ailment Online Mendelian Inheritance in Man ( OMIM) McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD), 2000. Internet URL: http://www.ncbi.nlm.nih.gov/omim/Protein-Disease Database (PDD) Maintained by NCI PharmGKB Thorn, Klein and Altman (2005) Methods Mol Biol., 311:179-91.

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From: Towards a proteome-scale guide of the human protein – protein collaboration arrange Rual, Vidal et al. Nature 437 , 1173-1178 (2005)

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From: Towards a proteome-scale guide of the human protein – protein connection arrange Rual, Vidal et al. Nature 437 , 1173-1178 (2005) Mining Alzheimer Disease Relevant Proteins from Integrated Protein Interactome Data Jake Yue Chen, Changyu Shen, and Andrey Y. Sivachenko Discovering Regulated Networks During HIV-1 Latency and Reactivation Sourav Bandyopadhyay, Ryan Kelley, and Trey Ideker Struct2Net: Integrating Structure into Protein-Protein Interaction Prediction Rohit Singh, Jinbo Xu, and Bonnie Berger

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Predicting and examining Protein communication locales Modeling and Analyzing Three-Dimensional Structures of Human Disease Proteins Yuzhen Ye, Zhanwen Li, and Adam Godzik Identifying Interaction Sites in "Recalcitrant" Proteins: Predicted Protein and RNA Binding Sites in Rev Proteins of HIV-1 and EIAV Agree with Experimental Data Michael Terribilini, Jae-Hyung Lee, Changhui Yan, Robert L. Jernigan, Susan Carpenter, Vasant Honavar, and Drena Dobbs Accounting for Structural Properties and Nucleotide Co-varieties in the Quantitative Prediction of Binding Affinities of Protein-DNA Interactions Sumedha Gunewardena and Zhaolei Zhang Improving Computational Predictions of Cis-Regulatory Binding Sites Mark Robinson, Yi Sun, Rene Te Boekhorst, Paul Kaye, Rod Adams, Neil Davey, and Alistair G. Rust

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What is next? Displaying natural procedures Modeling and Simulation with Hybrid Functional Petri Nets of the Role of Interleukin-6 in Human Early Haematopoiesis Sylvie Troncale, Fariza Tahi, David Campard, Jean-Pierre Vannier, and Janine Guespin

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Protein Interactions in Disease 8:50-9:10         Modeling and Analyzing Three-Dimensional Structures of Human Disease Proteins Yuzhen Ye, Zhanwen Li, and Adam Godzik 9:10-9:30         Mining Alzheimer Disease Relevant Proteins from Integrated Protein Interactome Data Yue Chen, Shen, and Sivachenko 9:30-9:50         Modeling and Simulation with Hybrid Functional Petri Nets of the Role of Interleukin-6 in Human Early Haematopoies Troncale, Tahi, Campard, Vannier, and Guespin 9:50-10:10       Identifying Interaction Sites in "Stubborn" Proteins: Predicted Protein and RNA Binding Sites in Rev Proteins of HIV and EIAV Agree with Experimental Data Terribilini, Lee, Yan, Jernigan, Carpenter, Honavar, and Dobbs 10:10-10:30     Struct2Net: Integrating Structure into Protein-Protein Interaction Prediction Singh, Xu, and Berger 10:30-10:50     Discovering Regulated Networks During HIV-1 Latency and Reactivation Bandyopadhyay, Kelley, and Ideker 10:50-11:30    Coffee Break 11:30-1:00       Discussion Session: Protein Interactions in Disease

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