Review: Wellbeing, Security, and Ecological Issues for Nanotechnology.


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Diagram: Health, Safety, and Environmental Issues for Nanotechnology ... Nanotechnology: Health, Safety, and Environment. Hse nano introduction jty.ppt changed 05-04-04 ...
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Review: Health, Safety, and Environmental Issues for Nanotechnology James Yardley May 7, 2004

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Nanotechnology: Health, Safety, and Environment.

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Occurance of nanoscale particulate materials. From presentation E. Clayton Teague, NNCO, April 2004.

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Potential bio-uptake of nanoscale particulates. Nanoparticles may enter living cells through: Endocytosis Receptor actuation for start Membrane entrance Generally happens with exceptionally hydrophobic particles Transmembrane channels May be seen with little nanoparticles (< 5 nm?) Adapted from presentation of Vicki Colvin, Rice University.

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Potential bio-gathering of nanoscale particles. Gathering of a substance inside an animal varieties can happen because of absence of debasement or discharge. Numerous nanoparticles are not biodegradable. On the off chance that nanoparticles enter living beings low in the nourishment web, they might be required to gather in life forms higher in the sustenance web. Almost no is comprehended about conceivable wellbeing impacts of nanoparticle presentation! Adjusted from presentation of Vicki Colvin, Rice University.

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Potential human perils for nanoscale particulates. Inward breath : Inhaled particles prompt aggravation in respiratory tract, bringing about tissue harm. Case: Inhalation of silica particles in mechanical laborers causes " silicosis " . Dermal presentation : Particles may enter body through the skin. Potential perils are obscure at present. Ingestion : nanoparticles may bring about liver harm. Ingested nanoparticles (i.e. for oral medication conveyance) have been found to amass in the liver. Intemperate resistant/incendiary reactions cause perpetual liver harm. Other : visual, … . Adjusted from presentation of Vicki Colvin, Rice University.

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Semiconductor nanoparticules. Red-and green-radiating quantum specks highlight the mitochondria and cores, separately, of human epithelial cells in society. In spite of the fact that these brilliant nanocrystals don\'t appear to hurt the cells, would they be able to posture unanticipated dangers to individuals or the earth? Silica-covered semiconductor nanocrystals are promptly fused into a wide assortment of eukaryotic cells. In tests where the quantum spots are stored on a collagen substrate and after that cells are kept on top of this, the cells consolidate any quantum dabs that underlie them When the cells move on a substrate, they ingest all the dabs they disregard giving an advantageous and quick path for evaluating the cells\' capability to metastasize, or spread (as a disease) starting with one a player in the body then onto the next [Adv. Mater., 14, 882 (2002)]. The spots seem to go into cells as "inert spectators." The cells stay sound and even keep on dividing, with every cell division decreasing the quantity of dabs in any given cell. The spots have no perceptible impact on the cells. - A. Paul Alivisatos

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Wahrheit (Dupont), January 2004. Optical micrograph of lung tissue from a rodent presented to single-divider carbon nanotubes (1 mg/kg) 1 week post presentation. Note the early improvement of injuries encompassing the ingrained SWCNT (bolts) and the nonuniform, diffuse example of single-divider carbon nanotube particulate testimony in the lung (X 100). Low-amplification micrograph of lung tissue from a rodent presented to single-divider carbon nanotubes (1 mg/kg) at 1 month postinstillation. Note the diffuse example of granulomatous sores (bolts). It was fascinating to note that couple of injuries existed in a few flaps while different projections contain a few granulomatous sores — and this was likely because of the nonuniform testimony design taking after carbon nanotube instillation. Amplification X 20. Higher amplification optical micrograph of lung tissue from a rodent presented to single-divider carbon nanotubes (1 mg/kg) at 1 month postinstillation presentation. Note the discrete, multifocal mononuclear granuloma based on the carbon nanotube material (bolts). Amplification X 400. D. B. Wahrheit et. al. Toxilogical Sciences 77, 117-125 (2004)

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Presentation, ACS, January, 2004 From Lam presentation

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From Lam presentation

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From Lam presentation

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From Lam presentation

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From Lam presentation

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Concerns about granulomas and strands. Granulomas (miscropic knobs), comprising particles, live and dead cells, and trash and could impede cell and physiological (gas trade) lung capacities and offer ascent to fibrosis, more characterized knobs, and different injuries. Strands are by and large of more wellbeing peril than different types of particulates. It is entrenched that the pathogenicity of a fiber in the lungs specifically associates with its biopersistency(Oberdorster 2000). NTs are absolutely insoluble and presumably a standout amongst the most organically nondegradable man-made materials.Determining how the NT-incited granulomas advancement would require a more drawn out span study with this biopersistent material. From Lam presentation

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Observations and speculative conclusions. • Granulomas were seen in lungs 7 d or 90 d after an instillation of 0.5 mg NT for each mouse (additionally in some with 0.1 mg); • NT, in any case manufactured strategies, sorts and measures of remaining synergist metals, delivered granulomas; • Lung injuries in the 90-d NT bunches, much of the time, more declared than those in the 7-d bunches. • Our study demonstrates that, on an equivalent weight premise, if carbon nanotubes achieve the lungs, they are considerably more harmful than carbon dark and can be more lethal than quartz, which is viewed as a genuine word related wellbeing peril in constant inward breath exposures. • If fine NT tidies are available in a workplace, presentation security techniques ought to be executed to minimize human exposures. From Lam presentation

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Governmental control - particulate matter. From presentation E. Clayton Teague, NNCO, April 2004.

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Problem zones for direction of particulates. From presentation E. Clayton Teague, NNCO, April 2004.

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NSF Guidelines for Nanocenter Research. Solid synthetic and materials cleanliness. HS&E instructive system for all participants. Protection against inward breath and dermal introduction. Appropriate methods for treatment of possibly risky materials. Strict adherence to government and institutional directions. Legitimate transfer of waste materials. Scattering of data in regards to potential perils. Appropriate reporting of all reportable incidents.

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