Speaking to research center data and different discoveries in clinical ontologies.


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SNCT Rheumatoid joint pain (issue) 69896004 (primitive) Is an Arthropathy related ... 1987 overhauled criteria for the grouping of rheumatoid joint pain. ...
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Speaking to lab data and different discoveries in clinical ontologies Anita Burgun, MD, PhD EA 3888-IFR140 Faculté de Médecine – Université de Rennes1 - France Signs, Symptoms and Findings: First Steps Toward an Ontology of Clinical Phenotypes Workshop, Sept 3-4, 2008 - Dallas, TX

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Two issues Interoperability Mapping vocabularies (Olivier) Metadata (Olivier) Integrate this data Databases (interoperability) Knowledge bases Ontology??

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LOINC and different wordings Names and codes 6-hub format "parts" the name of the segment or analyte measured its property (substance focus, mass, volume) the planning of the estimation the framework (serum, pee, and so forth.) the size of estimation (subjective versus quantitative, and so on.) the technique (in the event that it is applicable RIA, Immune Blot, and so on.). Research facility tests Sodium:SCnc:Pt:Ser/Plas:Qn Sodium:SerumConcentration:point-in-time:Serum-or-plasma: quantitative Component : Property : Time : System : Scale : Method

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LOINC and different wordings 37,000 lab tests 44,000 "sections" Overlap amongst LOINC and far reaching medicinal phrasings, for example, SNOMED CT Mapping Not lexical Based on the relations Component + framework 20% Bodenreider O. Issues in mapping LOINC research facility tests to SNOMED CT, AMIA 2008

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LOINC and others Observable UMLS SGs : Concepts & Ideas - Physiology mix Cigarettes smoked, complete (pack/yr) (C0489470) RR interim (C0489636) comprehended as worldly, subjective, or quantitative ideas and also physiological things. Pretended by noticeable

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Enrich ailment ontologies with signs (inc lab test comes about) Diabetes mellitus (jumble) Is a Disorder of endocrine pancreas Is a Disorder of glucose digestion system Is a Disorder of glucose direction Finding site Endocrine pancreatic structure (body structure) Finding site Structure of digestive framework (body structure) Ectopic hyperinsulinism (issue) Is a Disorder of endocrine pancreas Is a Disorder of glucose control Finding site Endocrine pancreatic structure (body structure) Finding site Structure of digestive framework (body structure) WHO indicative criteria for diabetes: fasting plasma glucose >= 7.0mmol/l (once in the past 7.8) or 2-h plasma glucose >= 11.1mmol/l). American Diabetes Association criteria IFT : Impaired Fasting Glycemia (6.1-7) IGT : Impaired Glucose Tolerance

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SNCT Rheumatoid joint pain (issue) 69896004 (primitive) Is an Arthropathy connected with an excessive touchiness response (disorder)  Is an Autoimmune ailment (issue) Is a Delayed extreme touchiness (issue) Due to Immune touchiness response (issue) Has definitional indication Immune framework (discovering) Pathological procedure Autoimmune (qualifier esteem) Associated morphology Inflammation (morphologic variation from the norm) Finding site Joint structure (body structure)

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Medical portrayal of RA Arnett FC, et al. The American Rheumatism Association 1987 modified criteria for the order of rheumatoid joint inflammation. Joint inflammation Rheum. 1988 Mar;31(3):315-24. morning firmness in and around joints enduring no less than 1 hour before maximal change delicate tissue swelling (joint pain) of 3 or more joint zones saw by a doctor swelling (joint inflammation) of the proximal interphalangeal, metacarpophalangeal, or wrist joints symmetric swelling (joint pain) rheumatoid knobs the nearness of rheumatoid variable radiographic disintegrations and/or periarticular osteopenia close by and/or wrist joints. Reference ontologies right/left mean 2 Modality of obtaining overlook the onlooker and spotlight on the swelling

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Arnett FC, et al. The American Rheumatism Association 1987 overhauled criteria for the grouping of rheumatoid joint inflammation. Joint inflammation Rheum. 1988 Mar;31(3):315-24. figured from an examination of 262 patients with RA and 262 control subjects with rheumatic ailments other than RA (non-RA). morning firmness in and around joints enduring no less than 1 hour before maximal change delicate tissue swelling (joint pain) of 3 or more joint regions saw by a doctor swelling (joint inflammation) of the proximal interphalangeal, metacarpophalangeal, or wrist joints symmetric swelling (joint pain) rheumatoid knobs the nearness of rheumatoid element radiographic disintegrations and/or periarticular osteopenia close by and/or wrist joints. RA is characterized by the nearness of 4 or more criteria . shown 91-94% affectability and 89% specificity for RA when contrasted and non-RA rheumatic ailment control subjects.

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Representing criteria : parallel with organizing frameworks and evaluating frameworks Kumar, Dameron Gliomas: WHO reviewing framework Formal meanings of WHO evaluations Marquet G, et al. Reviewing glioma tumors utilizing OWL-DL and the NCI Thesaurus, AMIA 2007

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signs - > avoids (negative prescient quality) Grade I or evaluation II or evaluation III « NoGrade » IV

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Take into record semiology in philosophy Burgun A, Bodenreider O, Jacquelinet C. Issues in the grouping of infection occasions with ontologies. Stud Health Technol Inform. 2005;116:695-700. Should be spoken to Automatize +++ Modularize : clinical signs (warmth, swelling), natural (ESR > 40), pathology (leukocytes inflitration), radiological the significant criteria for conclusion of OA is joint torment. This is differentiated to radiographic criteria, in which numerous patients don\'t report joint torment Formal definitions Grades Disorders, for example, paleness Organize characterized classes as subclasses of primitive classes Criteria showed 91-94% affectability and 89% specificity for RA Rheumatoid-Arthritis [Primitive] Subclass Rheumatoid-Arthritis [Defined: grouping A] Subclass Rheumatoid-Arthritis [Defined: order B] Meta-thinking : a few characterizations with various Se, Sp

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Acknowledgments O. Dameron, PhD, EA 3888 - portrayal rationales Julie Chabalier, PhD, EA 3888 - depiction rationales Régis Duvauferrier, MD, EA 3888; Service d\'Imagerie Médicale - clinician Olivier Bodenreider, MD, PhD - MIE paper, remarks

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