Summer 2007 Workshop in Science and Mixed media for Secondary Teachers:.


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Less liberal governmental issues. Utilization of abundance fetuses from IVF permitted ... Banter in US. Government subsidizing accessible for examination utilizing the Bush lines just: ES cell ...
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Summer 2007 Workshop in Biology and Multimedia for High School Teachers

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Stem Cell Research Overview Straight Path

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Outline What are Stem Cells? Potential Uses for Stem Cells Cloning Stem Cells and Cancer Worldwide Status What do you think? Outline

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What are Stem Cells? Undeveloped cells are not quite the same as every single other cell in the body. Immature microorganisms have 2 particular properties: They are unspecialized cells that are equipped for reestablishing (recovering) for drawn out stretches of time. They can offer ascent to various cell sorts (separation).

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Stem Cell Differentiation http://stemcells.nih.gov/data/nuts and bolts/basics4.asp

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Embryonic Obtained from in vitro preparation, or prematurely ended developing lives 3 or 4 day old incipient organism; blastocyst stage Adult Found among some separated cells in a particular tissue or organ; placental rope; infant teeth 2 sorts of Stem Cells

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Unique Properties of Stem Cells Regeneration Stem cells can repeat themselves over longer timeframes than other body cells Differentiation Stem cells are unspecialized cells that can create specific body cells by first delivering a go-between cell http://www.kumc.edu/stemcell/images.html

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Differentiation Animation Differentiation (http://learn.genetics.utah.edu/units/biotech/microarray/)

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Embryonic Stem Cells - Blastocyst Stage 3 sections: Trophoblast Blastocoel ("blastoseel") or blastocyst depression Inner cell mass Millions of cells can originate from one blastocyst http://www.kumc.edu/stemcell/images.html

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Blastocyst Vocabulary Trophoblast - external shell of blastocyst. Blastocoel - liquid filled space inside blastocyst. Inward cell mass - gathering of 30+ cells toward one side of the blastocoel, this is the thing that creates the particular cells required for grown-up life.

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Stem Cell Potential

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Pluripotent Differentiation http://www.kumc.edu/stemcell/images.html

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Adult Stem Cells (ASC) ASCs are undifferentiated cells found among separated cells in a tissue or organ They can recover and separate into the significant cell kind of the tissue or organ in which they are found. (Multipotent) Recent examinations have raised the likelihood that undifferentiated cells from one tissue/organ can make other cell sorts This is known as PLASTICITY

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http://www.stemcellresearch.org/declaration/20040929prentice.htm Reprinted with consent of Do No Harm.

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Adult Stem Cell Facts Adult foundational microorganisms were found in numerous a bigger number of tissues than anticipated Some might have the capacity to separate into various diverse cell sorts, given the right conditions General accord among researcher: Adult immature microorganisms DO NOT have as much potential as embryonic undifferentiated cells CLARIFICATION : not all new grown-up cells emerge from undeveloped cells Most emerge by MITOSIS of separated cells

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Potential Uses for Stem Cell Research Basic exploration – elucidation of complex occasions that happen amid human improvement & understanding atomic premise of tumor Biotechnology (drug revelation & advancement) – foundational microorganisms can give particular cell sorts to test new medications

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Potential Uses Continued. . . . Cell based treatments : Regenerative treatment to treat Parkinson\'s, Alzheimer\'s, ALS, spinal rope damage, stroke, serious blazes, coronary illness, diabetes, osteoarthritis, and rheumatoid joint inflammation Stem cells in quality treatment Stem cells as vehicles after they have been hereditarily controlled Stem cells in restorative cloning Stem cells in growth

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How Do You Make Stem Cells? Treated Egg Isolate blastocyst Remove internal cell mass Place into petri dish covered with feeder cells to advance division Differentiation!

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Cloning Reproductive Cloning Producing new life forms hereditarily indistinguishable to contributor Therapeutic Cloning Make a restorative item (immunization, human protein and so on) Deliver organs that won\'t be rejected Act as creature models for human infection Breeding creatures or plants with hereditarily great characteristics (hereditary designing)

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SCNT - Somatic Cell Nuclear Transfer 1. Expel core from egg cell and insert core from patient\'s cell to make treated egg. Expel internal cell mass from blastocyst and spot in petri dish for undeveloped cell advancement & separation Cells will be verging on indistinguishable to patient so dismissal won\'t happen when transplantated. 2. 3. http://www.kumc.edu/stemcell/early.html Reprinted with consent from the University of Kansas Medical Center.

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http://www.stemcellresearch.org/declaration/20040929prentice.htm Reprinted with authorization of Do No Harm.

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Problems with Therapeutic Cloning (1) Some resistant dismissal may happen - WHY? Around 1% of DNA in the clone won\'t be indistinguishable to patient It will be indistinguishable to egg cell utilized as a part of SCNT due to the mitochondrial DNA in the cytoplasm of the egg cell

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Problems with Therapeutic Cloning Large number of eggs required for SCNT which must be acquired with: Excessive hormone treatment of females Surgery to evacuate eggs Both procedures are possibly unsafe to females!

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Tumor undeveloped cell Tumor cell Current Efforts with SC and Cancer Determine contrast between growth & typical immature microorganisms Identify potential focuses in pathways basic for the survival of disease SCs Develop treatments that particularly target malignancy SC Duke University Explanation Drawn by Christine Rodriguez

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Status of SC exploration in different nations Great Britain Very liberal strategies on examination Therapeutic cloning permitted, utilization of abundance fetuses & making of incipient organisms permitted Stem cell research permitted France Less liberal legislative issues Use of overabundance fetuses from IVF permitted Reproductive AND remedial cloning banned Germany Very strict approaches Use of overabundance developing lives and production of fetuses banned Scientists can IMPORT fetuses Click here to see a guide of the undifferentiated cell arrangement around the world!

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Debate in US Federal subsidizing accessible for examination utilizing the Bush lines just: ES cell lines that were at that point in presence by 8/9/01 Disadvantage of Bush immature microorganism lines: May have lost regenerative capacity May have collected changes or diseases Private organizations keep on pursueing foundational microorganism research Use of human fetuses for IVF (in vitro preparation) & restorative cloning is lawful in many expresses No government financing Some states are thinking about banning both

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Global Status Ongoing open deliberation with respect to utilization of developing lives United Nations: proposition for a worldwide approach to boycott conceptive cloning just

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What do you think? Click on the connection to take a survey on YOUR supposition with respect to utilizing cloning for undifferentiated cell research. Cloning for Stem Cell Research Poll

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Summary Stem Cell Review Film Clip

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References Stem cells & Cloning Stem cells & Cloning; David A. Prentice, Benjamin Cummings, 2003 http://www.pbs.org/wgbh/nova/sciencenow/3302/06.html http://www.stemcellresearch.org http://www.stemcells.nig.gov/data/nasics/nasics7.asp http://www.stemcells.nig.gov/information/scireport/2006report.htm http://www.whitehouse.gov/news/discharges/2001/08/20010809-2.html Stem cells in class; Badran, Shahira; Bunker Hill Community College, 2007, Boston Museum of Science Biotechnology Symposium Harvard Stem Cell Institute