Systemic solidness: a determinant of circulatory strain .


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Julius Center for Health Sciences and Primary Care. Foundation pulse. early life root of essential hypertensionblood weight - blood vessel divider stiffnessarterial divider firmness - atherosclerosisarterial divider solidness - clinical diseaseblood weight - connective tissue vascular divider. Julius Center for Health Sciences and Primary Care.
Transcripts
Slide 1

Systemic firmness: a determinant of circulatory strain? Cuno Uiterwaal Julius Center Rick Grobbee Julius Center Ralph Sakkers Paediatric orthopedics Paul Helders Child Physical treatment Ruud Bank TNO/LUMC Raoul Engelbert Child Physical treatment Julius Center for Health Sciences and Primary Care

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Background circulatory strain early life inception of essential hypertension pulse - blood vessel divider solidness blood vessel divider firmness - atherosclerosis blood vessel divider solidness - clinical malady circulatory strain - connective tissue vascular divider Julius Center for Health Sciences and Primary Care

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Background Blood weight mostly dictated by vessel divider connective tissue digestion system just restricted digestion system or systemic? Julius Center for Health Sciences and Primary Care

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Background Connective tissue: collagen, elastin, crosslinks a wide range of structures tissue particular piece/digestion system a few similitudes in various tissues Julius Center for Health Sciences and Primary Care

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Childhood hypermobility disorders Part of demonstrative devices Joint hypermobility skin hyperextensibility Julius Center for Health Sciences and Primary Care

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Background joint portability and cardiovascular sickness restricted in diabetes mellitus (microangiopathy?) constrained in hypertensives?? next to no examination skin extensibility no exploration Julius Center for Health Sciences and Primary Care

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Research address: general Is the connection between pulse and tissue firmness bound to the ardiovascular framework? Julius Center for Health Sciences and Primary Care

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Research address: particular Is pulse identified with joint portability skin extensibility muscle quality bone quality in prepubertal youngsters? Julius Center for Health Sciences and Primary Care

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Childhood determinants of circulatory strain Age sex body tallness body weight family BP levels Julius Center for Health Sciences and Primary Care

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Childhood determinants of joint versatility/skin extensibility age sexual orientation body stature body weight family levels race Julius Center for Health Sciences and Primary Care

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Study configuration: subjects Cross-area of 95 Caucasian youngsters two elementary school in Zeist (NL) analyzed: November 2000 Julius Center for Health Sciences and Primary Care

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Study outline: estimations anthropometry pulse (OMRON) joint portability: goniometry skin extensibility: standard vacuum weight muscle quality: score bone quality: ultrasound os calcis surveys Julius Center for Health Sciences and Primary Care

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General attributes

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Median (range) joint movement left Julius Center for Health Sciences and Primary Care

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Median (range) skin extensibility left Julius Center for Health Sciences and Primary Care

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Blood weight and systemic solidness

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Adjustment: age, sex, weight, tallness

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Mutual reliance of different organs

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Discussion underpowered examine determination/data inclination? turn around causality? obscure or remaining puzzling? Julius Center for Health Sciences and Primary Care

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Conclusions Part of the connection between circulatory strain and tissue firmness might be systemic Julius Center for Health Sciences and Primary Care

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