THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS .


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Reason To explore the impacts of prostaglandin analogs and prostamids on visual surface in rats.. THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS. THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS. IntroductionLong-term utilization of topically directed antiglaucomatous drug can affect incendiary changes on the conjunctiva and cornea
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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Selim Doganay, MD ¹ ; Soner Demirel, MD ¹ ; Iclal Gurses, MD ² ; Mustafa Iraz, MD ³ Inonu University School of Medicine, Malatya-Turkey ¹ Department of Ophthalmology, ² Department of Pathology, ³ Department of Pharmacology Authors have no money related or exclusive enthusiasm for any instrument or items utilized as a part of this review

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Purpose To examine the impacts of prostaglandin analogs and prostamids on visual surface in rats.

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Introduction Long-term utilization of topically regulated antiglaucomatous prescription can incite provocative changes on the conjunctiva and corneal surface. ¹ Topical treatment may impact the achievement of glaucoma surgery . ²

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Materials and strategies 23 Wistar pale skinned person rats were separated into four gatherings ; 0.03 % bimatoprost (n=6) (Group 1) 0.005 % latanoprost (n=5) (Group 2) 0.004 % travoprost (n=8) (Group 3) Control amass (n=4) got no treatment Drugs were dropped reciprocally once every day , amid six month s .

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Materials and techniques At the finish of the six month, enucleation was performed then the eyes were segmented and recolored with hematoxylin-eosin (HE) and Masson\'s tric h rome for light infinitesimal examination. Dysplasia and keratinization on the visual surface w ere assessed . Number of lymphocytes and pole cells were meant five adjoining high-control fields (x 400) on the limbal conjunctival subepit h elial range. Collagen organization was assessed by stain ing thickness with trichrome .

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Results Dysplasia was not seen on corneal and conjunctival epithelium . Corneal and conjunctival keratinization was seen just in bimatoprost gather \'s (3/12) and latanoprost aggregate \'s (1/10) . THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS K eratinization of corneal surface epithelium ( )

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Results Mean lymphocytes numbers were 1.4 ± 0.19, 2.2 ± 0.39, 2.27 ± 0.33, and 1.87 ± 0.35 in gatherings , separately. There was no noteworthy distinction between all gatherings (p>0.05).

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Results Mean pole cells tallies were 2.58 ± 0.5, 5.4 ± 1.1, 5.7 ± 0.58, and 3.0±0.59 in gatherings , individually. Latanoprost gathering\'s and travoprost gathering\'s pole cell tallies were more than others gathering\'s (p<0.05).

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Results Mean collagen trichrome recoloring thickness scores were 1.0 ± 0.85, 2.0 ± 0.0, and 1,73 ± 0.7 in gatherings, separately. Latanaprost gathering\'s and travoprost gathering\'s trichrome recoloring thickness were more than bimatoprost gathering\'s (p<0.05). No distinction between latanoprost gathering\'s and travoprost gathering\'s (p>0.05).

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Control\'s (a), bimatoprost\'s (b), Travoprost\'s (c), and l atanaprost \'s (d) t richrome recoloring . a b c d

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS Conclusion s Long-term utilization of antiglaucomatous medications may bring about visual surface changes. Constant fiery changes seen in latanoprost gathering\'s and travoprost gathering\'s were more than bimatoprost gathering\'s in our review. The conceivable reason of these impacts may be contrasts of additive fixation, pH , and dynamic fixings in medications definition.

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THE EFFECT OF PROSTAGLANDIN ANALOGS AND PROSTAMIDS ON OCULAR SURFACE IN RATS References 1. Broadway DC, Grierson I, O\'Brien C, Hitchings RA Adverse impacts of topical antiglaucoma solution. I. The conjunctival cell profile. Curve Ophthalmol.1994;112: 1437-45. 2. Flach AJ. Does medicinal treatment impact the accomplishment of trabeculectomy? Trans Am Ophthalmol Soc. 2004;102:219-23.

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