PROPERTIES OF BETA-BLOCKERS Drug B-1 Selective ISA Lipid Solubility Daily Dose Equiva- lence Major Route of Elimination Once Daily Dosing - PDF Document

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PROPERTIES OF BETA-BLOCKERS Drug B-1 Selective ISA Lipid Solubility Daily Dose Equiva- lence Major Route of Elimination Once Daily Dosing

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  1. PROPERTIES OF BETA-BLOCKERS Drug B-1 Selective ISA Lipid Solubility Daily Dose Equiva- lence Major Route of Elimination Once Daily Dosing Yes 1+ Low-Mod 200mg Acebutolol1 Atenolol1 Bisoprolol1 Hepatic, Renal Yes Yes Yes -- -- Low Mod 50mg 5mg Renal Yes Hepatic, Renal Yes Carvedilol1 No -- Mod 25mg Hepatic No Esmolol1 Labetalol1 Metoprolol1 Nadolol1 Oxprenolol Pindolol Propranolol1 Yes -- Low Blood Esterases No No Yes -- -- Mod Mod 200mg 100mg Hepatic No Hepatic Yes (SR prep'n) No No No -- 2+ 3+ Low Mod Mod 80mg 80mg 7.5mg Renal Yes Hepatic No Hepatic, Renal Yes No -- High 80mg Hepatic Yes (LA prep'n) Sotalol1 Timolol No No -- -- Low Low 80mg 10mg Renal No Hepatic No 1 formulary drug; ISA = Instrinsic Sympathomimetic Activity 43