Spatial Discrimination in A T Maze: Acquisition and Reversal in BL and FVB Strains

Spatial Discrimination in A T Maze: Acquisition and Reversal in BL and FVB Strains
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This study examines the acquisition and reversal of spatial discrimination in a T maze by comparing BL and FVB strains through trials to criterion.

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1. SPATIAL DISCRIMINATION IN A T MAZE Trials to criterion Trials to criterion BL/6 strain FVB strain ACQUISITION AND REVERSAL 0 10 20 30 40 50 60 Day 1 Day 2 Day 3 Day 4 Day 5 Day 16 0 10 20 30 40 50 60 Day 1 Day 2 Day 3 Day 4 Day 5 Day 16 60 0 10 20 30 40 50 Day 17 Day 18 Day 19 Day 20 REPETITION 0 10 20 30 40 50 60 Day 17 Day 18 Day 19 Day 20 A B C D

2. PERSEVERATIVE RESPONSE Perseverative errors 0 1 2 3 4 5 Day 2 Day 3 Day 4 Day 5 Day 16 0 1 2 3 4 5 Day 2 Day 3 Day 4 Day 5 Day 16 SPATIAL DISCRIMINATION IN A T MAZE BL/6 strain FVB strain RETENTION Retention delay % of correct responses 30 40 50 60 70 80 90 100 5 min 24 hrs chance Retention delay 30 40 50 60 70 80 90 100 5 min 24 hrs chance A B

3. DISCRIMINATION SPATIALE DANS UN LABYRINTHE EN T KO WT

4. DISCRIMINATION SPATIALE DANS UN LABYRINTHE EN T Erreurs perseveratives % de reponses correctes WT KO RETENTION 30 40 50 60 70 80 90 100 5 mn 24 h chance Delai 30 40 50 60 70 80 90 100 5 mn 24 h chance Delai Souche FVB Souche BL/6